Screening of Potential Cancer-inhibiting Agents
نویسندگان
چکیده
منابع مشابه
Mechanism-based in vitro screening of potential cancer chemopreventive agents.
Identification and use of effective cancer chemopreventive agents have become an important issue in public health-related research. For identification of potential cancer chemopreventive constituents we have set up a battery of cell- and enzyme-based in vitro marker systems relevant for prevention of carcinogenesis in vivo. These systems include modulation of drug metabolism (inhibition of Cyp1...
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Antibodies against Pseudomonas aeruginosa (PA) lectin, PAIIL, which is a virulence factor mediating the bacteria binding to epithelium cells, were prepared in chickens and purified from egg yolks. To examine these antibodies as a prophylactic agent preventing the adhesion of PA we developed a well plate assay based on fluorescently labeled bacteria and immortalized epithelium cell lines derived...
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Diabetic nephropathy (DN) is the leading cause of end-stage renal disease (ESRD). The development and progression of DN might involve multiple factors. Connective tissue growth factor (CCN2, originally known as CTGF) is the one which plays a pivotal role. Therefore, increasing attention is being paid to CCN2 as a potential therapeutic target for DN. Up to date, there are also many drugs or agen...
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A theory of carcinogenesis developed by War burg (16) and others postulates the selection by anaerobic conditions toward the survival of malig nant cells as a result of altered glycolytic metabo lism. Moreover, some investigators believe that malignant neoplasms may develop preferentially in chronic hypoxia. In the first notable experimen tal induction of cancer by oxygen deficiency, Goldblatt ...
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Much progress has been made in cancer screening over the past decade, but a great deal more needs to be done if screening is to make a major impact on worldwide cancer mortality. Where fully implemented, cytological screening for cervical precursor lesions has had a major impact on mortality. However, the cost and required infrastructure levels are high, and new approaches are needed if screeni...
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ژورنال
عنوان ژورنال: Science
سال: 1951
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.113.2925.61